GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.81 | 5.66E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | CEP63 | chr3:134204575-134293852:+ | 0.22 | 3.83 | 0.00015 | Height |
| BLCA | cis | rs80285556 | 1 | rs55914901 | chr19:50528346 | SIGLEC16 | chr19:50472912-50479075:+ | 0.53 | 5.14 | 4.33E-7 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| BLCA | cis | rs60843830 | 1 | rs55936726 | chr2:258210 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.96 | 3.11E-28 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs60843830 | 1 | rs55946380 | chr2:268293 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.79 | 1.36E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9902453 | 1 | rs55971458 | chr17:28427016 | EFCAB5 | chr17:28256874-28435469:+ | 0.23 | 3.91 | 0.000109 | Coffee consumption (cups per day) |
| BLCA | cis | rs2243480 | 1 | rs56016656 | chr7:65383481 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.47 | 1.02E-5 | Diabetic kidney disease |
| BLCA | cis | rs9475752 | 1 | rs56030203 | chr6:56783857 | BEND6 | chr6:56819773-56892138:+ | -0.29 | -4.06 | 6.01E-5 | Menarche (age at onset) |
| BLCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | EIF3C | chr16:28722782-28747052:+;chr16 | 0.31 | 5.57 | 4.69E-8 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| BLCA | cis | rs8049439 | 1 | rs56040780 | chr16:28861881 | EIF3CL | chr16:28699879-28747052:+;chr16 | 0.34 | 5.33 | 1.64E-7 | Educational attainment;Inflammatory bowel disease (early onset);Educational attainment (years of education) |
| BLCA | cis | rs11622475 | 1 | rs56060232 | chr14:104386165 | TDRD9 | chr14:104394817-104519002:+ | 0.34 | 5.41 | 1.11E-7 | Bipolar disorder |
| BLCA | cis | rs2985684 | 1 | rs56098064 | chr14:50105849 | RPL36AL | chr14:50085407-50087349:- | 0.21 | 3.84 | 0.000144 | Carotid intima media thickness |
| BLCA | cis | rs9815354 | 1 | rs56121764 | chr3:41883975 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.5 | 2.29E-19 | Diastolic blood pressure |
| BLCA | cis | rs12748152 | 1 | rs56139710 | chr1:27269788 | GPN2 | chr1:27205873-27216869:- | 0.48 | 4.1 | 5.14E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs56145559 | 1 | rs56145559 | chr2:73623439 | ALMS1P | chr2:73872046-73912692:+ | 0.34 | 4.95 | 1.1E-6 | Schizophrenia |